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Antibiotic induced changes to mitochondria result in potential contributions to carcinogenesis.

Jorma Jyrkkanen

Mitochondrial job and creation of toxic mix by antibiotic Mitochondria, a primitive endosymbiotic bacteria, related to extant SARII marine bacteria and Rickettsias, in eukaryotes is responsible for Oxidative Phosphorylation (OP) and ATP and NAD production, when exposed to clinically equivalent doses of antibiotics that target bacteria (cipromycin, ampicillin, kanamycin), exhibited a decline in glutathione titre, an increase in Reactive Oxygen (ROS) and an increase in lipid peroxide [1,2]. Modes of action of antibiotics on mitochondria and microbiome 1. Quinolones: Commonly prescribed antibacterial organofluorine compounds that act by inhibition of bacterial DNA synthesis and result in rapid cell death [3]. They could be expected to do collateral damage to mitochondria and the human microbiome. This group contains Ofloxacin, Norfloxacin (Noroxin), Ciprofloxacin (Cipro), Moxifloxacin (Avelox)