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Development of sepsis in relation to serum biomarkers concentration like intercellular adhesion molecule-1, macrophage migration inhibitory factor, plasminogen activator inhibitor-1 and soluble Fas ligand

Linda Bara, Jelena Eglite, Peteris Oss, Vinita Cauce, Elvira Hagina, Sandra Gintere, Ludmila Viksna and Angelika Krumina

Sepsis is a condition with high mortality rates and its diagnosis remains a challenge. Therefore, a new diagnostic biomarker or combinations of biomarkers for diagnosis of sepsis should be developed. In total, 80 patients who were suspected of having sepsis were followed up for 7days. Quick Sepsis-related Organ Failure Assessment (qSOFA) scores were calculated day 1 and day 7; four biomarkers (intercellular adhesion molecule-1, macrophage migration inhibitory factor, plasminogen activator inhibitor-1 and soluble Fas ligand) results were evaluated the same. In 7 days in sepsis patients, blood serum concentrations of biomarker intercellular adhesion molecule-1 (ICAM-1) increased, p=0.022.