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Diabetic neuropathic pain: Neurogenic Diabetic problems

Dr. Elijah Walton

Over 90% of diabetics suffer from diabetic neuropathy, a common complication of both type 1 and type 2 diabetes. Although pain is one of the most common signs of diabetic neuropathy, the pathophysiological mechanisms underlying it are still poorly understood. Although a number of other hypotheses have been proposed, it is generally agreed that the harmful effects of hyperglycaemia are a major cause of this complication. Diabetic neuropathic pain is mostly treated by excluding other causes of painful peripheral neuropathy, improving glycaemic control as a preventative measure, and taking painkillers. Anticonvulsants like pregabalin and gabapentin, as well as antidepressants that block the reuptake of serotonin and noradrenaline are the first-line treatments for pain. Additionally, there is experimental and clinical evidence to suggest that opioids can aid in pain management, particularly when used in conjunction with first-line medications. Capsaicin cream and lidocaine patches, both of which can be applied topically, have also been suggested as potential adjuvants for the treatment of diabetic neuropathic pain, but there is insufficient clinical evidence to support their use. In conclusion, gaining a deeper comprehension of the mechanisms that lie behind diabetic neuropathic pain will not only aid in the search for brand-new treatments but also in the development of better guidelines for maximizing pain management with the medications that are currently available.