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Intraductal papilloma of the breast: Short-review

Shinya Tajima, Ichiro Maeda, Keiko Kishimoto, Saeko Naruki, Akira Endo, Masatomo Doi, Motohiro Chosokabe, Koichiro Tsugawa, Masayuki Takagi, Junki Koike

Intraductal papilloma is a common disease in the breast with clinical manifestation of nipple discharge. Hence many Core Needle Biopsy (CNB) is done in suspected intraductal papilloma. However, in the CNB specimen, sometimes it is difficult to determine whether the tumor is benign or malignant. In such situations, myoepithelial markers of p63 and calponin are useful immunostaining. And also high-molecular weight cytokeratins of CK5/6 and CK14 are helpful staining. Recently the report of two cases entitled “Nuclear inverse polarity papillary lesion lacking myoepithelial cells” is reported. This lesion resembles intraductal papilloma and thought to be at the most a tumor of uncertain malignant potential. Hence to diagnose intraductal papilloma, one should be careful even though problematic cases.