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Mild Oxidative Damage in the Diabetic Rat Heart Is Attenuated by Glyoxalase

Rubler WH

Diabetes significantly increases the threat of heart failure. The increase in advanced glycation end products (periods) and oxidative stress have been associated with diabetic cardiomyopathy. We lately demonstrated that there’s a direct link between periods and oxidative stress. Thus, the end of the current study was to probe if a reduction of periods by overexpression of the glycation precursor detoxifying enzyme glyoxalase-I (GLO- I) can help diabetes- convinced oxidative damage, inflammation and fibrosis in the heart. Diabetes was convinced in wild- type and GLO- I transgenic rats by streptozotocin. After 24- weeks of diabetes, cardiac function was covered with ultrasound.