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Parkinsonism-hyperpyrexia syndrome-A rare case report

Aishwarya Ghule, Sourya Acharya, Vidya Hulkoti and Yash Gupte

Parkinsonism-Hyperpyrexia Syndrome (PHS) though rare, is a catastrophic treatment-related complication of Parkinson’s Disease (PD). It is a hypodopaminergic state which occurs due to the abrupt withdrawal of dopaminergic medications in patients with PD. Clinically PHS resembles neuroleptic malignant syndrome (NMS). We report a case of a 66-year-old male who was diagnosed with PD 12 years earlier and was on Levodopa (200 mg)+Carbidopa (50 mg) twice a day and Tablet Selegeline 5 mg once in the morning. He had abruptly stopped taking medications because he went on a trip to his relative’s place and presented to us with hyperpyrexia and acute kidney injury. He recovered after the reinstitution of levodopa.