Абстрактный

Part of Shifts in RNA processing is treatment-specific

Zhi-Long Xiu

Environmental disquiet has large goods on both organismal and cellular traits, including gene expression and RNA processing. Analyses of RNA processing response have largely concentrated on genome-wide studies of response to individual chemical and natural agents or large scale defenses of medicine emulsion libraries with journalist minigenes. Utmost of the individual agents delved are applicable for cancer remedy, due to their capability to induce DNA damage (UV radiation treatment has also been delved in this environment). A genome-wide study of the splicing changes in mortal colon and bone cancer cell lines (HCT116 and MCF7) in response to the factory alkaloid camptothecin (CPT) used an exon microarray to study splicing and linked indispensable exon operation generally within splicing factors.