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Renal sympathetic denervation: indications, contemporary devices and future directions

J Sathananthan, T Watson, RJ Whitbourn, JT Stewart, RN Doughty, JA Ormiston & MWI Webster

Resistant essential hypertension that does not respond to standard treatment regimens poses an important therapeutic challenge. Catheterbased sympathetic renal denervation (RDN) therapy is an exciting and promising new treatment strategy, with potential to revolutionize the current treatment paradigm in this group of patients. This review will focus on contemporary evidence supporting the utility of RDN, review current and emerging devices, consider potential future treatment indications, and discuss unresolved issues that need to be addressed before RDN can be embraced as mainstream therapy.