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Sex differences in clinical outcomes following coronary revascularization

PH Lee & D-W Park

There have been several reports suggesting that the response to treatment for patients with significant coronary heart disease was not equal among males and females. Most of the early investigations on sex differences after surgical or percutaneous coronary revascularization suggested worse clinical outcomes in females compared with male counterparts. However, along with the advent of new revascularization techniques and devices, recent trials have shown somewhat narrowed sex-based differences in cardiovascular outcomes. Given that sex-based difference in outcomes and prognosis is still an important ongoing issue, this article systematically reviewed the cumulative evidence from key clinical studies and tried to help guide the physician in making sex-specific treatment decisions for patients with significant coronary heart disease requiring coronary revascularization.