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Sexual Dimorphism in Brain Content of Microglial Cells in Neonate Mice

Maryam Khajeh-Mobarakeh, Farshad Homayouni Moghadam

Brain microglia is known as resident immune cells in the brain. These cells begin to appear in the brain during the embryonic period and are of non-neural origin. Part of the evolution of the brain is related to the function of microglia and their role on neuro-developmental genderrelated structural differences in the brain. Also, there are gender-related differences in the neuro-immunological responses in the brain, for instance, in the female brain there is the phenomenon of microchimerism. To study microglia, primary cells or immortal microglia cells can be used, however, recent findings show that primary microglia are more in line with the reality of the brain. In this study, we assessed the culture specificities of male and female primary microglia extracted from the neonate mice.