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Solid State Fermentation Technology using Bioreactors Design, Applications, and Technical Considerations

Gómez Pablo

Due to its many advantages over submerged fermentation, solid-state fermentation (SSF) technology has gained significant acceptance in recent years (SMF). The complete potential of SSF technology has not yet been fully utilised at an industrial scale, despite its huge advantages. The fundamental cause of this is still the absence of logical, scalable bioreactor designs supported by automated control systems and mathematical models that could effectively handle heat and mass heterogeneity and function aseptically. Because of this, there is still a huge opportunity for SSF bioreactor research and development to support a wide range of biotechnological applications. The current paper analyses current SSF technology with a focus on bioreactors used for bioprocess applications, particularly enzyme production. Bioreactors are broken down into four categories based on how they operate, with a focus on design elements, how operating conditions affect productivity, applications, and restrictions. In order to address the restrictions, some modelling studies that have been generated throughout the years have been reworked and presented in a problem-specific way. We go into greater detail on a few intriguing designs, some of which have recently been suggested and/or used in pilot and commercial settings [1-3].