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The relationship between the use of oral contraceptives and the risk of uterine leiomyoma in women of child bearing age of Han Chinese

Jun Ying, Dongyun Nie & Suwen Chen

Objective: To study the relationship between the use of oral contraceptives and the risk of uterine myoma in women of childbearing age in Han Chinese.

Methods: A case-control study was conducted in 650 women of childbearing age in China who were diagnosed as uterine leiomyoma. The patients were matched according to the ratio of 1: 1, and the questionnaire and health checklist were used to investigate the influence factor of uterine leiomyoma.

Results: There was no significant difference in education level, number of pregnancy, abortion number and genital tract infection between case group and control group (P>0.05). The proportion of one-time pregnancy, body mass index (BMI), the proportion of hypertension and oral contraceptive use in case group were higher than those of the control group (P<0.05). The proportion of oral contraceptives currently used in the case group was higher than that of the control group (P<0.05). Women currently using oral contraceptives have a 1.91-fold greater risk of uterine leiomyoma than women who never used oral contraceptives (OR=1.91, 95% CI:1.22-2.94). Multivariate logistic regression analysis showed that the incidence of uterine leiomyoma in women of childbearing age with oral contraceptives and BMI ≥ 25 kg/m² was slightly increased (P<0.05).

Conclusion: Currently, the use of oral contraceptives and BMI ≥ 25 kg/m² were the risk factors for the incidence of uterine leiomyoma in Chinese women of childbearing age.