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Viruses and Type 1 diabetes: a dynamic labile equilibrium

Darius A Schneider & Matthias G von Herrath

Type 1 diabetes (T1D) results from the specific immune-mediated destruction of the insulin-producing b-cells of the pancreas. In genetically susceptible individuals, a still undetermined initiating ‘hit’ triggers a cascade of events that eventually leads to autoreactive CD8 T cells infiltrating the pancreatic islets and, subsequently, destroying them. There is increasing evidence that viruses, especially enteroviruses, are major environmental candidates; however, despite decades of investigation, we still lack certainty with regard to the causation of T1D. Moreover, studies in animal models of diabetes suggest a protective role of certain enteroviral infections upon diabetes contraction, making the quest for viral involvement inT1D even more difficult. Analyzing the foundation and the results of the most current work in the field, this article gives a brief overview of current knowledge, as well as providing an outlook for future directions.